• Description
• Additional information

About NSP Nanosoft Polymers (NSP)  specializes in  bridging the gap between polymer and drug delivery by supplying ready-to-use funcitonalized polymer & copolymers  for use in therapeutics, devices and diagnostics. NSP manufactures and sells a unique collection of functional polymers,  copolymers, and polymer conjugates. NSP's polymer catalog includes functional PLGA-PEG, PLA-PEG, PCL-PEG, lipid-PEGs, poly(L-lysine)-PEG, poly(L-glutamic acid)-PEG and pegylation reagents that can be used in your research involving drug/gene delivery, encapsulation, cell adhesion and surface modification. NSP also specializes in  polymer synthesis and functionalization, nanoparticle fabrication, surface modificaiton, and custom synthesis of reactive oligomers and polymers with a broad range of molecular weights.  Our Mission   We are dedicated to building a long-term, trusting relationship with our customers  by offering quality functional polymers and copolymers backed up with exceptional customer service and technical support.  High quality We guarantee the superior quality of our products by providing real analytical data  with excellent lot-by-lot reproducibility. Quick delivery We keep catalog items in stock. Overnight delivery is possible in US. Delivery is quick to other worldwide locations, too. Simple payment We accept NET 30 days payments, Credit cards, checks, and wire transfers. Great pricing We provide excellent pricing for our products. Check out our catalog now and compare the prices with our competitors. Professional support We provide the highest level of technical support to our customers.  Fast turnaround  Our experienced team work together to make sure quick turnaround for your orders. New products Nanosoft Polymers offers multiarm PLGAs for drug delivery  and biomedical research! Nanosoft Polymers offers Functional linear polyamino acids for drug delivery and surface modification! Nanosoft Polymers offers functionalized PEI-PEGs for in vitro and in vivo gene delivery! Nanosoft Polymers offers Functional linear polyamino acids for drug delivery and surface modification! Nanosoft Polymers offers Folate-PEG-PLA/PLGAfor targeted nanoparticles!   Nanosoft Polymers offers DSPE-PEG-DBCO for copper-free click chemistry! Nanosoft Polymers offers DSPE-PEG-Azide for bioconjugation by "click chemistry"! Nanosoft Polymers offers PLGA-PEG-Maleimide, and PLGA-PEG-Amine for gene/drug delivery!  Nanosoft Polymers offers Azide-PEG-PLL and Azide-PEG-pAsp for gene/drug delivery! Nanosoft Polymers offers custom synthesis for your special demand. Please contact us! NSP Products In Literature Optimization of cRGDfK ligand concentration on polymeric nanoparticles to maximize cancer targeting Posted on November 4, 2019 Optimization of ligand density on polymeric nanoparticles (PNPs) is critical for targeting solid tumors.  Recently, one paper published paper prepared fluorescent cyanine 5.5 dye and cyclo(arginine–glycine–aspartic acid–phenylalanine–lysine) ligand-modified polyethylene glycol-poly(lactic-co-glycolic acid) (Cy 5.5-cRGDfK-PEG-PLGA) NPs with different ligand concentrations and investigated their cancer-targeting abilities in vitro and in vivo. The PNPs self-assembled in an aqueous solution as round particles and showed an increase in their average size as a function of cRGDfK concentration. In vitro results revealed a gradual increase in the uptake of NPs in MDA-MB-435 breast cancer cells in a time- and ligand concentration-dependent manner. In vivo, NPs with 6 w/w% cRGDfK concentration showed prolonged uptake by the cancer tissue during the 7-day test period. These results suggest that Cy 5.5-cRGDfK6-PEG-PLGA NPs could serve as valuable drug carriers and diagnostic agents for the clinical treatment and targeting of solid cancers.  Journal of Industrial and Engineering Chemistry.  81, 25 January 2020, Pages 178-184. NSP’s Pegylated Lipid contributed to paper in Nano Letters Posted on October 16, 2019 Ultrathin Tellurium Oxide/Ammonium Tungsten Bronze Nanoribbon for Multimodality Imaging and Second Near-Infrared Region Photothermal Therapy Developing nanophotothermal agents (PTAs) with satisfied photothermal conversion efficiency (PTCE) in the second NIR window (1000–1350 nm, NIR II) holds great promise for enhanced photothermal therapy effect. Herein, we develop a NIR-II PTA with advanced PTCE, based on a new two-dimensional ultrathin tellurium oxide/ammonium tungsten bronze (TeO2/(NH4)xWO3) nanoribbons (TONW NRs). The doped ammonia ions-mediated-free-electrons injection into the lowest unoccupied molecular orbital band of WO3 combined with the electronic transitions between W6+ ions and the lone pair of electrons in Te atoms achieve excellent NIR absorption of TONW NRs resulting from localized surface plasmon resonance. The polyethylene glycol functionalized TONW NRs (PEG-TONW NRs) exhibit good stability and biocompatibility, displaying a PTCE high to 43.6%, surpassing many previous nano-PTAs active in the NIR II region, leading to remarkable tumor ablation ability both in vitro and in vivo. Meanwhile, advanced X-ray computed tomography (CT) and photoacoustic (PA) imaging capability of PEG-TONW NRs were also realized. Given the admirable photothermal effect in NIR II region, good biocompatibility, and advanced CT/PA imaging diagnosis capability, the novel PEG-TONW NRs is promising in future personalized medicine applications. Nano Lett.2019, 19, 2, 1179-1189.